Tcsol Biopharma

Mesalamine 500 mg prolonged-release tablets (also known as mesalazine) are an anti-inflammatory medication primarily used to treat and prevent flare-ups of mild to moderate ulcerative colitis and mild to moderate Crohn's disease. Key Information

• Mechanism of Action: Mesalamine is an aminosalicylate that works topically inside the intestines to reduce inflammation by blocking the production of certain chemical messengers (prostaglandins). This action helps to alleviate symptoms such as diarrhea, rectal bleeding, and abdominal pain.
• Administration: The tablets should be swallowed whole; they should not be broken, crushed, or chewed, as this would compromise the prolonged-release coating that allows the medicine to work in the lower parts of the digestive tract.
• Dosage: Dosing depends on the specific brand and condition being treated, so it must be taken exactly as prescribed by a doctor. It is important to drink plenty of fluids while taking this medication to help prevent kidney stones.
• Prescription Status: This medication is available only with a doctor's prescription. 

Common Side EffectsMost side effects are generally mild and may include:   

• Headache
• Nausea and vomiting
• Abdominal pain or cramping
• Diarrhea or flatulence
• Runny or stuffy nose and sore throat
• Back pain

Important Precautions

• Medical History: Inform your doctor if you have kidney or liver problems, a stomach blockage, or a history of heart inflammation (myocarditis or pericarditis).
• Allergies: Do not take mesalamine if you are allergic to it, or to aspirin or other salicylates.
• Medication Interactions: Tell your doctor about all medications you are taking, especially nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, and azathioprine or 6-mercaptopurine, as interactions may occur.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Untreated ulcerative colitis during pregnancy poses risks, but the doctor can help weigh the benefits and potential risks of the medication.
• Sun Sensitivity: Mesalamine may make your skin more sensitive to sunlight, so protective clothing and sunscreen are recommended. 

    Always consult a healthcare provider for medical advice regarding your condition and the use of this medication. Do not stop taking it suddenly without discussing it with your doctor first.           

Mesalamine delayed-release 400 mg tablets (brand names include Asacol® and generic versions) are a prescription anti-inflammatory medication used primarily to treat and prevent flare-ups of mild to moderate ulcerative colitis and, in some cases, Crohn's ileocolitis.   Key Information

• Active Ingredient: Mesalamine (also known as 5-aminosalicylic acid or 5-ASA).
• Mechanism: It works locally in the intestines to reduce inflammation, which helps alleviate symptoms such as diarrhea, rectal bleeding, and abdominal pain.
• Administration: The tablets must be swallowed whole with water. They should not be broken, crushed, or chewed, as this would prevent the delayed-release coating from working properly in the target area of the colon.
• Dosage: The dosage is determined by a doctor based on the patient's condition (e.g., treating an active flare-up versus maintenance therapy) and body weight, especially for children. A common adult dosage for an active flare-up might be two 400 mg tablets three times daily for six weeks. For maintenance, a total daily dose of 1.6 grams (four 400 mg tablets) can be given in divided doses or once daily.
• Prescription: This is a prescription medication and should only be used as directed by a healthcare provider. 

Important Considerations

• Medical Supervision: Regular monitoring of kidney and liver function is necessary during treatment.
• Potential Side Effects: Common side effects include headache, nausea, abdominal pain, and diarrhea. Serious, though rare, side effects can include allergic reactions (rash, trouble breathing), kidney problems, or worsening of colitis symptoms.
• Interactions: Inform your doctor about all other medications you are taking, especially nonsteroidal anti-inflammatory drugs (NSAIDs) or azathioprine, as they may increase the risk of kidney issues.
• Hydration: Drink plenty of fluids while on this medication to help prevent kidney stones.
• Brand Variation: Different brands and formulations of mesalamine are not always interchangeable (e.g., a 400 mg delayed-release capsule is not the same as an 800 mg delayed-release tablet), so do not switch brands without consulting your doctor. 

Mesalamine delayed-release 800 mg tablets, a prescription anti-inflammatory medication, are primarily used to treat and prevent flare-ups of mild to moderately active ulcerative colitis. They work by decreasing swelling and inflammation in the colon to reduce symptoms like diarrhea, rectal bleeding, and stomach pain.    Key Information

• Active Ingredient: Mesalamine (also known as mesalazine or 5-ASA).
• Strength: 800 mg.
• Form: Delayed-release (enteric-coated) tablets for oral administration. The delayed-release mechanism allows the medication to work inside the bowels where its effects are needed.
• Usage: It is a prescription drug; always follow your doctor's orders regarding the specific brand, dosage, and treatment duration.
• Administration: Tablets should be swallowed whole; do not split, chew, or crush them to maintain the protective delayed-release coating. Dosage varies, but for treatment of a flare-up, a common adult dosage is two 800 mg tablets three times daily for a total of 4.8 grams daily for six weeks. 

      Common Side EffectsCommon side effects may include:   

• Headache
• Nausea, vomiting, abdominal pain, diarrhea, gas
• Back pain or joint pain
• Dizziness
• Cold symptoms (stuffy nose, sore throat, sneezing)
• Rash 

Important Considerations

• Kidney Monitoring: Your doctor will likely order regular kidney function tests before and during treatment, as mesalamine can rarely affect kidney function.
• Medication Interactions: Inform your doctor about all medications you are taking. Avoid certain non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen and some antacids without consulting a healthcare provider first.
• Brand Consistency: Different brands of mesalamine are designed to release the medication in different parts of the gut. It is important to stick to the specific brand your doctor prescribes to ensure it works correctly. 

  For more detailed information, you can refer to authoritative sources like MedlinePlus Drug Information or the Mayo Clinic website.  

Mesalamine delayed-release 1200 mg tablets (also known by brand names like Lialda® and others) are a prescription anti-inflammatory medication used primarily to treat and manage symptoms of ulcerative colitis and, in some cases, Crohn's disease. Key Information

• Primary Use: It is used to induce and maintain remission in adults and some pediatric patients with mild to moderate active ulcerative colitis. It works locally in the colon to reduce inflammation, which helps relieve symptoms such as abdominal pain, diarrhea, and rectal bleeding.
• Mechanism: The delayed-release coating is designed to release the medication slowly and directly into the colon and terminal ileum, the areas where inflammation is present, minimizing systemic absorption and potential side effects in other parts of the body.
• Dosage and Administration:
  • It is crucial to take this medication exactly as prescribed by your doctor.
  • Swallow the tablet whole; do not split, chew, or crush it, as this would damage the special coating and affect how the drug works.
  • The 1200 mg delayed-release tablets (such as Lialda®) are typically taken once a day with food.
  • Drink plenty of fluids while taking mesalamine to help prevent kidney stones.
• Important Precautions:
  • Prescription Required: This medication is available only with a doctor's prescription.
  • Medical Conditions: Inform your doctor if you have kidney or liver problems, a blockage in your stomach, or a history of heart inflammation (myocarditis, pericarditis).
  • Allergies: Do not take this medication if you are allergic to mesalamine, salicylates (like aspirin), or any of its ingredients.
  • Interactions: Discuss all other medications and supplements you are taking with your doctor, as some, including certain NSAIDs (e.g., ibuprofen) and antacids, may interact with mesalamine.
  • Monitoring: Your doctor will likely monitor your kidney and liver function through blood and urine tests before and during treatment. 

       Common Side EffectsMost side effects are mild and disappear as your body adjusts to the medicine. They may include:   

• Headache
• Nausea and vomiting
• Diarrhea or stomach pain
• Gas or flatulence
• Joint or back pain
• Runny nose or sore throat

If you experience severe symptoms, such as a high fever, unusual bleeding, swelling of the face/tongue/throat, or worsening of your colitis symptoms (cramping, bloody diarrhea, fever, headache, rash), seek immediate medical attention.   For more comprehensive information, consult the MedlinePlus Drug Information page or the specific product's prescribing information provided by manufacturers on sites like DailyMed.