Tcsol Biopharma

Rabeprazole and domperidone capsules are a combination medication used to treat conditions like acidity, heartburn, and GERD (gastroesophageal reflux disease). Rabeprazole is a proton pump inhibitor that reduces stomach acid, while domperidone is a prokinetic agent that increases the movement of the stomach and intestines to help with nausea and vomiting. This combination helps relieve symptoms by decreasing acid production and improving digestion, and is also used for gastric and duodenal ulcers.  How they work

• Rabeprazole: Works by blocking the proton pump in the stomach lining, which significantly reduces the amount of acid produced. 
• Domperidone: Increases the movement and contractions of the stomach and intestines, allowing food to move through the digestive tract more easily. 

What they are used for

• Acidity
• Heartburn
• Gastroesophageal reflux disease (GERD)
• Gastric and duodenal ulcers
• Nausea and vomiting
• Bloating and gas 

Important considerations

• Dosage: The dose is determined by a doctor based on your condition and how you respond to the medication. 
• Side effects: Common side effects can include headache, diarrhea, abdominal pain, dizziness, and dry mouth. 
• Precautions: Consult your doctor before use if you are pregnant, planning a pregnancy, or breastfeeding. 
• Contraindications: The medication should not be used in patients with a history of certain heart arrhythmias. Patients with severe liver impairment should also avoid it. 
• Long-term use: Prolonged use of the rabeprazole component may affect the body's ability to absorb Vitamin B12. 
• Driving: Avoid driving or operating machinery if the medication causes dizziness or drowsiness. 

Aceclofenac-paracetamol tablets combine two medicines for pain relief, inflammation, and fever. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID), while paracetamol (acetaminophen) is an analgesic and antipyretic.    UsesThis combination is often prescribed for the short-term relief of pain and swelling in musculoskeletal conditions. Specific uses include:   

• Osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis: Conditions causing pain, inflammation, and stiffness in the joints.
• Musculoskeletal pain: Including back pain, neck pain, sprains, and strains.
• Dental pain: Pain associated with the teeth and jaw.
• Ear and throat pain: Pain caused by infections or inflammation.
• Post-operative pain: Pain experienced after surgery. 

     Dosage

• The medication is typically taken orally, with or after food, to minimize the risk of stomach upset.
• The frequency and duration are determined by a doctor based on the patient's condition, age, and medical history.
• It's important to follow the prescribed dosage and not exceed the recommended amount or duration. 

   Side effectsCommon side effects can include:   

• Nausea
• Diarrhea
• Dizziness
• Stomach pain
• Drowsiness
• Dyspepsia (indigestion) 

Serious risks: NSAIDs like aceclofenac can increase the risk of serious cardiovascular issues, such as heart attack and stroke.  Precautions

• Consult a doctor: You should always take this medication under the supervision of a healthcare professional.
• Take with food: To avoid an upset stomach, it is recommended to take the tablets with food or milk.
• Limit alcohol: You should avoid alcohol consumption while taking this medication.
• Liver and kidney disease: The drug should be used with caution in patients with liver or kidney conditions.
• Pregnancy and breastfeeding: This medication is generally not recommended during pregnancy or breastfeeding.
• Operating machinery: Avoid activities that require mental focus, such as driving, until you know how the medication affects you, as it can cause dizziness or drowsiness. 

AvailabilityAceclofenac-paracetamol is available under various brand names and as a generic drug. It may also be found in combination with other medications, such as serratiopeptidase, to further reduce swelling. 

Mebeverine Hydrochloride 135 mg is a prescription antispasmodic medication primarily used to relieve symptoms of Irritable Bowel Syndrome (IBS). It works by relaxing the smooth muscles of the gastrointestinal tract, which helps to ease abdominal pain, cramps, and bloating.   Common uses

• Irritable Bowel Syndrome (IBS): Mebeverine helps manage the painful spasms and irregular bowel movements associated with IBS.
• Functional bowel disorders: The medication is also used for conditions with similar symptoms, such as chronic irritable colon, mucous colitis, and spastic constipation. 

   Mechanism of action
As a musculotropic antispasmodic, mebeverine directly targets and relaxes the smooth muscles in the gut. This selective action relieves spasms and cramping without significantly affecting normal gut motility. While the exact process is not fully understood, it may involve affecting ion channels and muscarinic receptors.    Common side effects
While generally well-tolerated, some side effects may occur:  

• Skin rash or itching
• Nausea and vomiting
• Dizziness or lightheadedness
• Headache
• Indigestion or heartburn 

   Serious side effects, such as a severe allergic reaction (anaphylaxis) with swelling of the face, lips, or tongue and difficulty breathing, are rare but require immediate medical attention.  Important precautions and contraindications

• Medical consultation is required: Mebeverine is a prescription medication and should only be taken as directed by a doctor.
• Paralytic ileus: The drug is contraindicated in patients with paralytic ileus, a condition where the intestinal muscles stop working.
• Allergies: Do not use if you are allergic to mebeverine or any of its ingredients.
• Pregnancy and breastfeeding: Consult a doctor before use, as its safety during pregnancy is uncertain and it is expressed in breast milk.
• Liver and kidney disease: Patients with severe liver or kidney impairment should use mebeverine with caution.
• Porphyria: Individuals with this rare genetic disorder should not take mebeverine.
• Glaucoma: In very rare cases, it can trigger acute angle-closure glaucoma.
• Children: The standard 135 mg dose is not recommended for children under 10. 

    Common brand names in India
Mebeverine Hydrochloride 135 mg is available under several brand names in India, including: 

• Colospa
• Morease
• Mebaspa
• Mebstar
• Mebause 

How to take mebeverine hydrochloride 135 mg

• Follow your doctor's prescribed dosage and duration.
• Swallow the tablet whole with water. Do not chew or crush it.
• Take it about 20 minutes before meals to help control post-meal symptoms. 

BRAND NAME-NEUROSOL 400MG TABLETS

Piracetam is used in the treatment of Alzheimer's disease, stroke, dementia in Parkinson's disease, age related memory loss and head injury. Piracetam is a nootropic medicine. It works by increasing the activity of a chemical messenger (acetylcholine) which improves communication between the nerve cells.